Search for: All records

Land-use change may drive viral spillover from bats into humans, partly through dietary shifts caused by decreased availability of native foods and increased availability of cultivated foods. We experimentally manipulated diets of Jamaican fruit bats to investigate whether diet influences viral shedding. To reflect dietary changes experienced by wild bats during periods of nutritional stress, Jamaican fruit bats were fed either a standard diet or a putative suboptimal diet, which was deprived of protein (suboptimal-sugar diet) and/or supplemented with fat (suboptimal-fat diet). Upon H18N11 influenza A-virus infection, bats fed on the suboptimal-sugar diet shed the most viral RNA for the longest period, but bats fed the suboptimal-fat diet shed the least viral RNA for the shortest period. Bats on both suboptimal diets ate more food than the standard diet, suggesting nutritional changes may alter foraging behaviour. This study serves as an initial step in understanding whether and how dietary shifts may influence viral dynamics in bats, which alters the risk of spillover to humans. 

Abstract We present Atacama Large Millimeter/submillimeter Array observations of the [CI] 492 and 806 GHz fine-structure lines in 25 dusty star-forming galaxies (DSFGs) atz= 4.3 in the core of the SPT2349–56 protocluster. The protocluster galaxies exhibit a median $L_{\left[\text{C}\mathrm{I}\right](2-1)}^{\prime }/L_{\left[\text{C}\mathrm{I}\right](1-0)}^{\prime }$ratio of 0.94, with an interquartile range of 0.81–1.24. These ratios are markedly different to those observed in DSFGs in the field (across a comparable redshift and 850μm flux density range), where the median is 0.55, with an interquartile range of 0.50–0.76, and we show that this difference is driven by an excess of [Ci](2–1) in the protocluster galaxies for a given 850μm flux density. Assuming local thermal equilibrium, we estimate gas excitation temperatures of $T_{\mathrm{ex}}=59.1_{-6.8}^{+8.1}$K for our protocluster sample and $T_{\mathrm{ex}}=33.9_{-2.2}^{+2.4}$K for the field sample. Our main interpretation of this result is that the protocluster galaxies have had their cold gas driven to their cores via close-by interactions within the dense environment, leading to an overall increase in the average gas density and excitation temperature, as well as an elevated [Ci](2–1) luminosity-to-far-infrared-luminosity ratio. 

Abstract We present Atacama Compact Array (ACA) Band-3 observations of the protocluster SPT2349−56, an extreme system hosting >10 ultraluminous infrared galaxies (ULIRGs;L_IR ≳  10¹²L_⊙) in a 200 kpc diameter region atz =  4.3, to study its integrated molecular gas content via CO(4–3) and the long-wavelength dust continuum. The ∼30 hr integration represents one of the longest exposures yet taken on a single pointing with the ACA 7 m. The low-resolution ACA data (21 $\stackrel{\text{″}}{.}$0  ×  12 $\stackrel{\text{″}}{.}$2) reveal a 75% excess CO(4–3) flux compared to the sum of individual sources detected in higher-resolution Atacama Large Millimeter/submillimeter Array (ALMA) data (1 $\stackrel{\text{″}}{.}$0  ×  0 $\stackrel{\text{″}}{.}$8). Our work also reveals a similar result by tapering the ALMA data to 10″. In contrast, the 3.2 mm dust continuum shows little discrepancy between ACA and ALMA. A single-dish [Cii] spectrum obtained by APEX/FLASH supports the ACA CO(4–3) result, revealing a large excess in [Cii] emission relative to ALMA. The missing flux is unlikely due to undetected faint sources but instead suggests that high-resolution ALMA observations might miss extended and low-surface-brightness gas. Such emission could originate from the circumgalactic medium or the preheated protointracluster medium (proto-ICM). If this molecular gas reservoir replenishes the star formation fuel, the overall depletion timescale will exceed 400 Myr, reducing the requirement for the simultaneous ULIRG activity in SPT2349−56. Our results highlight the role of an extended gas reservoir in sustaining a high star formation rate in SPT2349−56 and potentially establishing the ICM during the transition phase to a mature cluster. 

Bats are reservoirs of many zoonotic viruses that are fatal in humans but do not cause disease in bats. Moreover, bats generate low neutralizing antibody titers in response to experimental viral infection, although more robust antibody responses have been observed in wild-caught bats during times of food stress. Here, we compared the antibody titers and B cell receptor (BCR) diversity of Jamaican fruit bats (Artibeus jamaicensis; JFBs) and BALB/c mice generated in response to T-dependent and T-independent antigens. We then manipulated the diet of JFBs and challenged them with H18N11 influenza A-like virus or a replication incompetent Nipah virus VSV (Nipah-riVSV). Under standard housing conditions, JFBs generated a lower avidity antibody response and possessed more BCR mRNA diversity compared to BALB/c mice. However, withholding protein from JFBs improved serum neutralization in response to Nipah-riVSV and improved serum antibody titers specific to H18 but reduced BCR mRNA diversity. 

Coevolution is common and frequently governs host–pathogen interaction outcomes. Phenotypes underlying these interactions often manifest as the combined products of the genomes of interacting species, yet traditional quantitative trait mapping approaches ignore these intergenomic interactions. Devil facial tumor disease (DFTD), an infectious cancer afflicting Tasmanian devils (Sarcophilus harrisii), has decimated devil populations due to universal host susceptibility and a fatality rate approaching 100%. Here, we used a recently developed joint genome-wide association study (i.e., co-GWAS) approach, 15 y of mark-recapture data, and 960 genomes to identify intergenomic signatures of coevolution between devils and DFTD. Using a traditional GWA approach, we found that both devil and DFTD genomes explained a substantial proportion of variance in how quickly susceptible devils became infected, although genomic architectures differed across devils and DFTD; the devil genome had fewer loci of large effect whereas the DFTD genome had a more polygenic architecture. Using a co-GWA approach, devil–DFTD intergenomic interactions explained ~3× more variation in how quickly susceptible devils became infected than either genome alone, and the top genotype-by-genotype interactions were significantly enriched for cancer genes and signatures of selection. A devil regulatory mutation was associated with differential expression of a candidate cancer gene and showed putative allele matching effects with two DFTD coding sequence variants. Our results highlight the need to account for intergenomic interactions when investigating host–pathogen (co)evolution and emphasize the importance of such interactions when considering devil management strategies. 

WISE J224607.6–052634.9 (W2246–0526) is a hot dust-obscured galaxy atz = 4.601, and the most luminous obscured quasar known to date. W2246–0526 harbors a heavily obscured supermassive black hole that is most likely accreting above the Eddington limit. We present observations with the Atacama Large Millimeter/submillimeter Array (ALMA) in seven bands, including band 10, of the brightest far-infrared (FIR) fine-structure emission lines of this galaxy: [OI]_63 μm, [OIII]_88 μm, [NII]_122 μm, [OI]_145 μm, [CII]_158 μm, [NII]_205 μm, [CI]_370 μm, and [CI]_609 μm. A comparison of the data to a large grid of CLOUDYradiative transfer models reveals that a high hydrogen density (n_H ∼ 3 × 10³cm⁻³) and extinction (A_V ∼ 300 mag), together with extreme ionization (log(U) = − 0.5) and a high X-ray to UV ratio (α_ox ≥ −0.8) are required to reproduce the observed nuclear line ratios. The values ofα_oxandUare among the largest found in the literature and imply the existence of an X-ray-dominated region (XDR). In fact, this component explains the a priori very surprising non-detection of the [OIII]_88 μmemission line, which is actually suppressed, instead of boosted, in XDR environments. Interestingly, the best-fitted model implies higher X-ray emission and lower CO content than what is detected observationally, suggesting the presence of a molecular gas component that should be further obscuring the X-ray emission over larger spatial scales than the central region that is being modeled. These results highlight the need for multiline infrared observations to characterize the multiphase gas in high redshift quasars and, in particular, W2246–0526 serves as an extreme benchmark for comparisons of interstellar medium conditions with other quasar populations at cosmic noon and beyond. 

Abstract We present the first spatially resolved maps of gas-phase metallicity for two dust-obscured star-forming galaxies atz∼ 4, from the JWST TEMPLATES Early Release Science program, derived from NIRSpec integral field unit spectroscopy of the Hαand [Nii] emission lines. Empirical optical line calibrations are used to determine that the sources are globally enriched to near-solar levels. While one source shows elevated [N ii]/Hαratios and broad Hαemission consistent with the presence of an active galactic nucleus in a ≳1 kpc region, we argue that both systems have already undergone significant metal enrichment as a result of their extremely high star formation rates. Utilizing Atacama Large Millimeter/submillimeter Array rest-frame 380μm continuum and [Ci](³P₂–³P₁) line maps we compare the spatial variation of the metallicity and gas-to-dust ratio in the two galaxies, finding the two properties to be anticorrelated on highly resolved spatial scales, consistent with various literature studies ofz∼ 0 galaxies. The data are indicative of the enormous potential of JWST to probe the enrichment of the interstellar medium on ∼kpc scales in extremely dust-obscured systems atz∼ 4 and beyond. 

Abstract We present JWST and Atacama Large Millimeter/submillimeter Array (ALMA) imaging for the lensing system SPT0418−47, which includes a strongly lensed, dusty, star-forming galaxy at redshiftz= 4.225 and an associated multiply imaged companion. The JWST NIRCam and MIRI imaging observations presented in this paper were acquired as part of the Early Release Science program Targeting Extremely Magnified Panchromatic Lensed Arcs and Their Extended Star formation (TEMPLATES). This data set provides robust mutiwavelength detections of stellar light in both the main (SPT0418A) and companion (SPT0418B) galaxies, while the ALMA detection of [Cii] emission confirms that SPT0418B lies at the same redshift as SPT0418A. We infer that the projected physical separation of the two galaxies is 4.42 ± 0.05 kpc. We derive total magnifications ofμ= 29 ± 1 andμ= 4.1 ± 0.7 for SPT0418A and SPT0418B, respectively. We use bothprospectorandcigaleto derive stellar masses. We find that SPT0418A has a stellar mass of $M_{*}={3.4}_{-0.6}^{+1.1}\times {10}^{10}{M}_{\odot }$fromprospector orM_*= 1.5 ± 0.3 × 10¹⁰M_⊙fromcigale. The stellar mass ratio of SPT0418A and SPT0418B is roughly between 4 and 7 ( ${4.2}_{-1.6}^{+1.9}$forprospectorand 7.5 ± 3.7 forcigale). We see evidence of extended structure associated with SPT0418A that is suggestive of a tidal feature. These features, along with the close projected proximity, imply that the system is interacting. Interestingly, the star formation rates and stellar masses of both galaxies are consistent with the main sequence of star-forming galaxies at this epoch, indicating that this ongoing interaction has not noticeably elevated the star formation levels.